3D culture technologies of cancer stem cells: promising ex vivo tumor models
C Zhang, Z Yang, DL Dong, TS Jang… - Journal of tissue …, 2020 - journals.sagepub.com
Cancer stem cells have been shown to be important in tumorigenesis processes, such as
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …
Three-dimensional models to study breast cancer
M Huerta-Reyes… - … Journal of Oncology, 2021 - spandidos-publications.com
Breast cancer (BC) is the most commonly occurring cancer and primary cause of cancer-
related mortality in women worldwide. Investigations into BC have been conducted in in vitro …
related mortality in women worldwide. Investigations into BC have been conducted in in vitro …
Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival
Pancreatic tumors are highly desmoplastic and poorly‐vascularized, and therefore must
develop adaptive mechanisms to sustain their survival under hypoxic condition. Extracellular …
develop adaptive mechanisms to sustain their survival under hypoxic condition. Extracellular …
An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues
Complex 3D bioengineered tumour models provide the opportunity to better capture the
heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to …
heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to …
[HTML][HTML] Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer niches
Extracellular matrix (ECM) stiffening is a common occurrence during the progression of
many diseases, such as breast cancer. To accurately mimic the pathophysiological context …
many diseases, such as breast cancer. To accurately mimic the pathophysiological context …
Multi compartmental 3D breast cancer disease model–recapitulating tumor complexity in in-vitro
Breast cancer is the most common ailment among women. In 2020, it had the highest
incidence of any type of cancer. Many Phase II and III anti-cancer drugs fail due to efficacy …
incidence of any type of cancer. Many Phase II and III anti-cancer drugs fail due to efficacy …
Culture of cancer spheroids and evaluation of anti-cancer drugs in 3D-printed miniaturized continuous stirred tank reactors (mCSTRs)
S Gallegos-Martínez, IM Lara-Mayorga… - …, 2022 - iopscience.iop.org
Cancer continues to be a leading cause of mortality in modern societies; therefore, improved
and more reliable in vitro cancer models are needed to expedite fundamental research and …
and more reliable in vitro cancer models are needed to expedite fundamental research and …
Three dimensional engineered models to study hypoxia biology in breast cancer
Breast cancer is the second leading cause of mortality among women worldwide. Despite
the available therapeutic regimes, variable treatment response is reported among different …
the available therapeutic regimes, variable treatment response is reported among different …
Developing a drug screening platform: MALDI-mass spectrometry imaging of paper-based cultures
Many potential chemotherapeutics fail to reach patients. One of the key reasons is that
compounds are tested during the drug discovery stage in two-dimensional (2D) cell cultures …
compounds are tested during the drug discovery stage in two-dimensional (2D) cell cultures …
Three-dimensional core-shell alginate microsphere for cancer hypoxia simulation in vitro
Y Ruan, L He, J Chen, J Wang, S Zhao… - … in Bioengineering and …, 2023 - frontiersin.org
Hypoxia is one of the major causes of cancer resistance and metastasis. Currently, it is still
lack of convenient ways to simulate the in vivo hypoxic tumor microenvironment (TME) under …
lack of convenient ways to simulate the in vivo hypoxic tumor microenvironment (TME) under …