Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

W Barrie, Y Yang, EK Irving-Pease, KE Attfield… - Nature, 2024 - nature.com
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …

Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution

GA Roberts Kingman, DN Vyas, FC Jones… - Science …, 2021 - science.org
Similar forms often evolve repeatedly in nature, raising long-standing questions about the
underlying mechanisms. Here, we use repeated evolution in stickleback to identify a large …

Estimating temporally variable selection intensity from ancient DNA data

Z He, X Dai, W Lyu, M Beaumont… - Molecular Biology and …, 2023 - academic.oup.com
Novel technologies for recovering DNA information from archaeological and historical
specimens have made available an ever-increasing amount of temporally spaced genetic …

Inference of selection from genetic time series using various parametric approximations to the Wright-Fisher model

C Paris, B Servin, S Boitard - G3: Genes, Genomes, Genetics, 2019 - academic.oup.com
Detecting genomic regions under selection is an important objective of population genetics.
Typical analyses for this goal are based on exploiting genetic diversity patterns in present …

Ecological processes shaping microbiomes of extremely low birthweight infants

C Zioutis, D Seki, F Bauchinger, C Herbold… - Frontiers in …, 2022 - frontiersin.org
The human microbiome has been implicated in affecting health outcomes in premature
infants, but the ecological processes governing early life microbiome assembly remain …

Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populations

W Barrie, Y Yang, EK Irving-Pease, KE Attfield… - bioRxiv, 2022 - biorxiv.org
Multiple sclerosis (MS) is a modern neuro-inflammatory and-degenerative disease, which is
most prevalent in Northern Europe. Whilst it is known that inherited risk to MS is located …

A numerical framework for genetic hitchhiking in populations of variable size

E Friedlander, M Steinrücken - Genetics, 2022 - academic.oup.com
Natural selection on beneficial or deleterious alleles results in an increase or decrease,
respectively, of their frequency within the population. Due to chromosomal linkage, the …

Bait‐ER: A Bayesian method to detect targets of selection in Evolve‐and‐Resequence experiments

C Barata, R Borges, C Kosiol - Journal of Evolutionary Biology, 2023 - academic.oup.com
For over a decade, experimental evolution has been combined with high‐throughput
sequencing techniques. In so‐called Evolve‐and‐Resequence (E&R) experiments …

[HTML][HTML] A novel expectation-maximization approach to infer general diploid selection from time-series genetic data

AG Fine, M Steinrücken - bioRxiv, 2024 - ncbi.nlm.nih.gov
Detecting and quantifying the strength of selection is a main objective in population
genetics. Since selection acts over multiple generations, many approaches have been …

Estimating temporally variable selection intensity from ancient DNA data with the flexibility of modelling linkage and epistasis

Z He, X Dai, W Lyu, M Beaumont… - Molecular Ecology …, 2023 - Wiley Online Library
Innovations in ancient DNA (aDNA) preparation and sequencing technologies have
exponentially increased the quality and quantity of aDNA data extracted from ancient …