Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms
L Xu, Y Li, Y Dai, J Peng - Pharmacological research, 2018 - Elsevier
Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …
Emodin: a review of its pharmacology, toxicity and pharmacokinetics
X Dong, J Fu, X Yin, S Cao, X Li, L Lin… - Phytotherapy …, 2016 - Wiley Online Library
Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese
medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum …
medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum …
Emodin-A natural anthraquinone derivative with diverse pharmacological activities
Abstract Emodin (1, 3, 8-trihydroxy-6-methyl-anthraquinone) is a natural anthraquinone
derivative that is present in numerous globally renowned herbal medicines. It is recognised …
derivative that is present in numerous globally renowned herbal medicines. It is recognised …
Hormetic effects of phytochemicals on health and longevity
Caloric restriction, intermittent fasting, and exercise activate defensive cellular responses
such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes …
such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes …
Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle
Gut microbes might influence host metabolic homeostasis and contribute to the
pathogenesis of type 2 diabetes (T2D), which is characterized by insulin resistance. Bacteria …
pathogenesis of type 2 diabetes (T2D), which is characterized by insulin resistance. Bacteria …
Emodin up‐regulates glucose metabolism, decreases lipolysis, and attenuates inflammation in vitro 大黄素在体内上调糖代谢, 减少脂解和抑制炎症反应
X Zhang, R Zhang, P Lv, J Yang, Y Deng… - Journal of …, 2015 - Wiley Online Library
摘要背景: 大黄素是掌叶大黄的主要生物活性成分, 具有多种的功效, 包括抗肿瘤,
抗炎以及预防糖尿病等作用. 最近有报道大黄素具有调节能量代谢的作用. 在本研究中 …
抗炎以及预防糖尿病等作用. 最近有报道大黄素具有调节能量代谢的作用. 在本研究中 …
Rutin potentiates insulin receptor kinase to enhance insulin‐dependent glucose transporter 4 translocation
CY Hsu, HY Shih, YC Chia, CH Lee… - Molecular Nutrition & …, 2014 - Wiley Online Library
Scope We investigated whether rutin, a flavonoid isolated from Toona sinensis Roem, has
the ability to enhance insulin‐dependent receptor kinase (IRK) activity and glucose …
the ability to enhance insulin‐dependent receptor kinase (IRK) activity and glucose …
Emodin ameliorates renal damage and podocyte injury in a rat model of diabetic nephropathy via regulating AMPK/mTOR-mediated autophagy signaling pathway
H Liu, Q Wang, G Shi, W Yang, Y Zhang… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Purpose The activation of autophagy has potential protective effect on diabetic nephropathy
(DN) podocyte injury, and the AMPK/mTOR signaling pathway is an important regulatory …
(DN) podocyte injury, and the AMPK/mTOR signaling pathway is an important regulatory …
Anti-neuroinflammatory effect of emodin in LPS-stimulated microglia: involvement of AMPK/Nrf2 activation
SY Park, ML Jin, MJ Ko, G Park, YW Choi - Neurochemical research, 2016 - Springer
AMPK/Nrf2 signaling regulates multiple antioxidative factors and exerts neuroprotective
effects. Emodin is one of the main bioactive components extracted from Polygonum …
effects. Emodin is one of the main bioactive components extracted from Polygonum …
Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway
Currently, obesity has become a worldwide epidemic associated with Type 2 diabetes,
dyslipidemia, cardiovascular disease and chronic metabolic diseases. Emodin is one of the …
dyslipidemia, cardiovascular disease and chronic metabolic diseases. Emodin is one of the …