Conspectus Membrane potential is a fundamental biophysical property maintained by every
cell on earth. In specialized cells like neurons, rapid changes in membrane potential drive …

Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …

The discovery of the first heart field (FHF) and the second heart field (SHF) led us to
understand how cardiac lineages and structures arise during development. However, it …

Cardiomyocytes undergo significant structural and functional changes after birth, and these
fundamental processes are essential for the heart to pump blood to the growing body …

The heart develops from 2 sources of mesoderm progenitors, the first and second heart field
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …

The ability to produce unlimited numbers of human induced pluripotent stem cell derived
cardiomyocytes (hiPSC-CMs) harboring disease and patient-specific gene variants creates …

Inhibition of autophagy, the major cellular recycling pathway in mammalian cells, is a
promising strategy for the treatment of triple-negative breast cancer (TNBC). We previously …

Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Currently,
many methods have been proposed by researchers for the prevention and treatment of …

Defining the mechanisms safeguarding cell fate identity in differentiated cells is crucial to
improve 1)-our understanding of how differentiation is maintained in healthy tissues or …

Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are
genetically complex and poorly understood. Here, a multidisciplinary platform was …