Skin injuries across the body continue to disrupt everyday life for millions of patients and
result in prolonged hospital stays, infection, and death. Advances in wound healing devices …

Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …

The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of
collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of …

Approved therapies for tendon diseases have not yet changed the clinical practice of
symptomatic pain treatment and physiotherapy. This review article summarizes advances in …

From the cell cytoskeleton to connective tissues, fibrous networks are ubiquitous in
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …

Key points The amount of fibrotic material in dystrophic mouse muscles relates to contractile
function, but not passive function. Collagen fibres in skeletal muscle are associated with …

Tendinopathy is labeled by many authors as a troublesome, common pathology, present in
up to 30% medical care consultations involving musculoskeletal conditions. Despite the …

This review highlights recent research on Achilles tendon healing, and comments on the
current clinical controversy surrounding the diagnosis and treatment of injury. The processes …

Muscle forces are essential for skeletal patterning during development. Eliminating muscle
forces, eg, through paralysis, leads to bone and joint deformities. Botulinum toxin (BtxA) …

This review highlights recent research on structure–function relationships in tendon and
comments on the parallels between development and healing. The processes of tendon …