Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Sickle cell disease (SCD) substantially alters renal structure and function, and causes
various renal syndromes and diseases. Such diverse renal outcomes reflect the uniquely …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from
erythrocytes to plasma. We investigated the concept that erythrocyte membrane …

This review presents evidence for two overlapping yet distinctive clinical types of sickle cell
disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of …

Complicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men.
Ang II–dependent TGF-β activity promotes aortic aneurysm progression in experimental …

Sickle human hemoglobin (Hb) confers a survival advantage to individuals living in endemic
areas of malaria, the disease caused by Plasmodium infection. As demonstrated hereby …

Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …