Chemical synthesis of β-lactams: asymmetric catalysis and other recent advances
The history of the β-lactam (2-azetidinone) ring, arguably one of the most acclaimed
heterocycles studied over the last century, tells a tale rich in curiosity, serendipity, and …
heterocycles studied over the last century, tells a tale rich in curiosity, serendipity, and …
Strategic approaches to the synthesis of pyrrolizidine and indolizidine alkaloids
NK Ratmanova, IA Andreev, AV Leontiev, D Momotova… - Tetrahedron, 2020 - Elsevier
The principal methods for the synthesis of pyrrolizidine and indolizidine alkaloids and their
unnatural analogs are described. Six main “strategic” approaches in regard to a key step …
unnatural analogs are described. Six main “strategic” approaches in regard to a key step …
Stereocontrolled cyclic nitrone cycloaddition strategy for the synthesis of pyrrolizidine and indolizidine alkaloids
The synthesis of polyhydroxylated indolizidines and pyrrolizidines belonging to the class of
iminosugars, endowed with a vast and assorted biological activity, can be achieved in a …
iminosugars, endowed with a vast and assorted biological activity, can be achieved in a …
Assignment of the absolute configuration of natural lentiginosine by synthesis and enzymic assays of optically pure (+) and (-)-enantiomers
The structure and absolute configuration of natural lentiginosine isolated from plant sources
was determined to be (lS, 2S, 8aS)-1, 2-dihydroxyindolizidine ((+)-4) on the basis of the …
was determined to be (lS, 2S, 8aS)-1, 2-dihydroxyindolizidine ((+)-4) on the basis of the …
Manganese dioxide oxidation of hydroxylamines to nitrones
Several structurally differentiated N, N-dialkylhydroxylamines were oxidised to the
corresponding nitrones using MnO2. Manganese dioxide revealed an efficient and mild …
corresponding nitrones using MnO2. Manganese dioxide revealed an efficient and mild …
A five-membered enantiopure cyclic nitrone from malic acid by regioselective oxidation of cyclic hydroxylamine. Synthesis of (1S, 7S, 8aR)-octahydro-1, 7 …
The mechanism of the dehydrogenation of N, jV-disub-stituted hydroxylamines to nitrones
has seen limited study, despite numerous reports on this reaction, and a clear-cut picture is …
has seen limited study, despite numerous reports on this reaction, and a clear-cut picture is …
Oxidation of secondary amines to nitrones using urea-hydrogen peroxide complex (UHP) and metal catalysts
E Marcantoni, M Petrini, O Polimanti - Tetrahedron letters, 1995 - Elsevier
Secondary amines can be readily oxidized to the corresponding nitrones using urea-
hydrogen peroxide complex (UHP) and metal catalysts in methanol at room temperature …
hydrogen peroxide complex (UHP) and metal catalysts in methanol at room temperature …
Enantiopure cyclic nitrones: A useful class of building blocks for asymmetric syntheses
The synthesis of enantiopure cyclic nitrones has become a frequently addressed topic in
discussions of their usefulness in the production of natural products and biologically active …
discussions of their usefulness in the production of natural products and biologically active …
Synthesis and Properties of (1R(S),5R(S),7R(S),8R(S))-1,8-Bis(hydroxymethyl)-6-azadispiro[4.1.4.2]tridecane-6-oxyl: Reduction-Resistant Spin Labels with …
YV Khoroshunova, DA Morozov, DA Kuznetsov… - International Journal of …, 2023 - mdpi.com
Site-directed spin labeling followed by investigation using Electron Paramagnetic
Resonance spectroscopy is a rapidly expanding powerful biophysical technique to study …
Resonance spectroscopy is a rapidly expanding powerful biophysical technique to study …
Iterative organometallic addition to chiral hydroxylated cyclic nitrones: Highly stereoselective syntheses of α, α '-and α, α-substituted hydroxypyrrolidines
Iteration of organometallic addition to chiral hydroxylated pyrroline N-oxides through an
addition-oxidation-addition synthetic sequence allowed highly stereoselective double …
addition-oxidation-addition synthetic sequence allowed highly stereoselective double …