Effective pharmacological management of pain associated with tissue pathology is an unmet
medical need. Transcriptional modifications in nociceptive pathways are pivotal for the …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Epigenetic mechanisms, including histone post-translational modifications (PTMs), play a
critical role in regulating pain perception and the pathophysiology of burn injury. However …

Burn injuries can be devastating, with life-long impacts including an increased risk of
hospitalization for a wide range of secondary morbidities. One area that remains not fully …

Scar formation is a normal response to skin injuries. During the scar-remodeling phase, scar
tissue is usually replaced with normal, functional tissue. However, after deep burn injuries …

Burn injury is a trauma resulting in tissue degradation and severe pain, which is processed
first by neuronal circuits in the spinal dorsal horn. We have recently shown that in mice …

The spinal dorsal horn transforms incoming somatosensory information and transmits it
supraspinally to generate modality-specific sensory percepts. The lack of an established …

Tissue injuries, including burns, are major causes of death and morbidity worldwide. These
injuries result in the release of intracellular molecules and subsequent inflammatory …

Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide
association studies (GWASs) have identified genetic variants predisposed to chronic pain …

Key mechanisms underlying chronic pain occur within the neural circuitry of the dorsal horn.
Recent genome-wide association studies (GWAS) have identified genetic variants …