Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all
contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in …

The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological
functions, and their ratio varies widely in breast cancers. To determine whether the two PR …

In recent years, a link between the transcriptional regulators of lineage-specific gene
expression and progenitor proliferation control has emerged. A main exponent of this …

Unlike most other organs, development of the mammary gland occurs predominantly after
birth, under the control of steroid and peptide hormones. Once the gland is established …

A considerable body of research indicates that mammary gland branching morphogenesis is
dependent, in part, on the extracellular matrix (ECM), ECM-receptors, such as integrins and …

Macrophages and dendritic cells (DC) are distributed throughout the body and play
important roles in pathogen detection and tissue homeostasis. In tissues, resident …

O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of nuclear and cytoplasmic
proteins is important for many cellular processes, and the number of proteins that contain …

Female fertility requires estrogen to specifically stimulate estrogen receptor α (ERα)-
dependent growth of the uterine epithelium in adult mice, while immature females show …

The CCAAT/enhancer-binding protein (C/EBP) family of transcription factors plays an
important role in controlling cell proliferation and differentiation. C/EBPα is a particularly …