[HTML][HTML] Orientia and Rickettsia: different flowers from the same garden

JJ Gillespie, J Salje - Current Opinion in Microbiology, 2023 - Elsevier
Recent discoveries of basal extracellular Rickettsiales have illuminated divergent
evolutionary paths to host dependency in later-evolving lineages. Family Rickettsiaceae …

Tumor necrosis factor regulates leukocyte recruitment but not bacterial persistence during Staphylococcus aureus craniotomy infection

Z Van Roy, T Kielian - Journal of Neuroinflammation, 2024 - Springer
Background Craniotomy is a common neurosurgery used to treat intracranial pathologies.
Nearly 5% of the 14 million craniotomies performed worldwide each year become infected …

Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in mice

Y Liang, Aditi, F Onyoni, H Wang, C Gonzales… - Frontiers in …, 2023 - frontiersin.org
Scrub typhus, an acute febrile illness caused by Orientia tsutsugamushi (Ot), is prevalent in
endemic areas with one million new cases annually. Clinical observations suggest central …

Exploring TNFR1: from discovery to targeted therapy development

Y Li, R Ye, H Dai, J Lin, Y Cheng, Y Zhou… - Journal of Translational …, 2025 - Springer
This review seeks to elucidate the therapeutic potential of tumor necrosis factor receptor 1
(TNFR1) and enhance our comprehension of its role in disease mechanisms. As a critical …

Histone Methyltransferase MLL1 Mediates Oxidative Stress and Apoptosis upon Deoxynivalenol Exposure in the Intestinal Porcine Epithelial Cells

D Shi, Y Shan, X Zhu, H Wang, S Wu, Z Wu, W Bao - Antioxidants, 2022 - mdpi.com
Deoxynivalenol (DON), as a secondary metabolite of fungi, is continually detected in
livestock feed and has a high risk to animals and humans. Moreover, pigs are very sensitive …

Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions

Y Liang, H Wang, K Sun, J Sun, L Soong - PLoS pathogens, 2024 - journals.plos.org
Scrub typhus is an acute febrile disease due to Orientia tsutsugamushi (Ot) infection and can
be life-threatening with organ failure, hemorrhage, and fatality. Yet, little is known as to how …

CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice

Y Liang, H Wang, C Gonzales, J Thiriot… - Frontiers in …, 2022 - frontiersin.org
Scrub typhus is a life-threatening zoonosis caused by the obligate intracellular bacterium
Orientia tsutsugamushi (Ot) that is transmitted by the infected larvae of trombiculid mites …

Differential cellular immune responses against Orientia tsutsugamushi Karp and Gilliam strains following acute infection in mice

JD Thiriot, Y Liang, C Gonzales, J Sun… - PLoS neglected …, 2023 - journals.plos.org
Scrub typhus is a leading cause of febrile illness in endemic countries due to infection with
Orientia tsutsugamushi (Ot), a seriously understudied intracellular bacterium. Pulmonary …

Alterations in germinal center formation and B cell activation during severe Orientia tsutsugamushi infection in mice

C Gonzales, Y Liang, J Fisher, G Card… - PLoS neglected …, 2023 - journals.plos.org
Scrub typhus is a poorly studied but life-threatening disease caused by the intracellular
bacterium Orientia tsutsugamushi (Ot). Cellular and humoral immunity in Ot-infected patients …

Comprehensive review on cardiac manifestation of scrub typhus

BP Sivasubramanian, AHS Abdul Khader… - Frontiers in Tropical …, 2024 - frontiersin.org
Scrub typhus, a zoonotic disease caused by Orientia tsutsugamushi and transmitted by
chiggers, predominantly affects the Asia-Pacific region. Complications of Scrub Typhus …