Integrated lncRNA function upon genomic and epigenomic regulation
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …
Circular RNA: metabolism, functions and interactions with proteins
WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …
that are ubiquitous across species ranging from viruses to mammals. Important advances …
Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma
L Liu, M Gu, J Ma, Y Wang, M Li, H Wang, X Yin, X Li - Molecular cancer, 2022 - Springer
Background Emerging evidence indicates that circular RNAs (circRNAs) and m6A RNA
methylation participate in the pathogenesis and metastasis of multiple malignancies …
methylation participate in the pathogenesis and metastasis of multiple malignancies …
RNA-binding proteins in tumor progression
H Qin, H Ni, Y Liu, Y Yuan, T Xi, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …
important biological functions. They are critical to maintain the transcriptome through post …
A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
Y Peng, Y Xu, X Zhang, S Deng, Y Yuan, X Luo… - Molecular cancer, 2021 - Springer
Abstract Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …
Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1
X Zang, J Jiang, J Gu, Y Chen, M Wang, Y Zhang… - Molecular Cancer, 2022 - Springer
Background Increasing studies suggest that circular RNAs (circRNAs) are critical regulators
of cancer development and progression. However, the biological roles and mechanisms of …
of cancer development and progression. However, the biological roles and mechanisms of …
CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
L Meng, Y Zhang, P Wu, D Li, Y Lu, P Shen, T Yang… - Molecular Cancer, 2022 - Springer
Background circular RNAs (circRNAs) have been reported to play crucial roles in the biology
of different cancers. However, little is known about the function of circSTX6 …
of different cancers. However, little is known about the function of circSTX6 …
[HTML][HTML] Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus
C Zhang, X Han, L Yang, J Fu, C Sun, S Huang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Macrophages play critical roles in the pathogenesis of type 1 diabetes mellitus
(T1DM). Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently …
(T1DM). Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently …
CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer
X Wang, J Li, X Bian, C Wu, J Hua… - Proceedings of the …, 2021 - National Acad Sciences
Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their
modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI1 …
modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI1 …