The role of inflammation in autoimmune disease: a therapeutic target

Y Xiang, M Zhang, D Jiang, Q Su, J Shi - Frontiers in Immunology, 2023 - frontiersin.org
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …

MIF contribution to progressive brain diseases

A Matejuk, G Benedek, R Bucala, S Matejuk… - Journal of …, 2024 - Springer
Progressive brain diseases create a huge social and economic burden on modern societies
as a major cause of disability and death. Incidence of brain diseases has a significantly …

B cell involvement in the pathogenesis of ankylosing spondylitis

R Wilbrink, A Spoorenberg, GMPJ Verstappen… - International journal of …, 2021 - mdpi.com
Extensive research into ankylosing spondylitis (AS) has suggested the major role of
genetics, immune reactions, and the joint–gut axis in its etiology, although an ultimate …

The role of neutrophils in spondyloarthritis: A journey across the spectrum of disease manifestations

LA Coletto, C Rizzo, G Guggino, R Caporali… - International Journal of …, 2023 - mdpi.com
Spondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal
system, gut, skin, and eyes, delineating heterogeneous diseases with a common …

Recent updates in enthesitis-related arthritis

R Naveen, S Guleria, A Aggarwal - Rheumatology International, 2023 - Springer
Enthesitis-related arthritis (ERA) is a category of juvenile idiopathic arthritis which belongs to
the spectrum of diseases that are included in juvenile spondyloarthropathy. In recent years …

Single‐cell RNA sequencing reveals the CRTAC1+ population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1+ macrophage

Y Tang, D Zhuo, Y Yu, W Pu, Y Ma, Y Zhang… - Aging …, 2024 - Wiley Online Library
Degenerative spinal stenosis is a chronic disease that affects the spinal ligaments and
associated bones, resulting in back pain and disorders of the limbs among the elderly …

Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity

L Chen, L Li, D Cui, Y Huang, H Tong, H Zabihi… - Molecular …, 2024 - Elsevier
Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate
obesity. We investigate the role of cytokine, macrophage migration inhibitory factor (MIF) in …

Pathogenesis, assessment, and management of bone loss in axial spondyloarthritis

A Nakamura, T Towheed - Seminars in Arthritis and Rheumatism, 2024 - Elsevier
Introduction Axial spondyloarthritis (axSpA) presents a complex scenario where both new
bone formation in entheseal tissues and significant trabecular bone loss coexist …

The gut-enthesis axis and the pathogenesis of Spondyloarthritis

D Mauro, A Nakamura, N Haroon, F Ciccia - Seminars in immunology, 2021 - Elsevier
Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show
features of dysbiosis, altered gut barrier function, and local expansion of innate and innate …

Role of neutrophil interleukin-23 in spondyloarthropathy spectrum disorders

T Macleod, C Bridgewood… - The Lancet Rheumatology, 2023 - thelancet.com
Neutrophilic inflammation is a pervasive characteristic common to spondyloarthropathies
and related disorders. This inflammation manifests as Munro's microabscesses of the skin …