NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …

Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide,
presenting at any age, and leading to a substantial burden for individuals and society. It is …

Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …

Introduction: Generalized pustular psoriasis (GPP) is a rare, severe relapsing/remitting,
multisystem disease that can be difficult to treat. Recent clinical, histological, and genetic …

Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction
between inherited susceptibility alleles and environmental triggers. In the last decade …

Psoriasis is a common inflammatory skin disease involving interactions between
keratinocytes and immune cells that significantly affects the quality of life. It is characterized …

Abstract CARD protein–BCL-10–MALT1 (CBM) signalosomes are multiprotein signalling
platforms that control immune and inflammatory pathways in most tissues. After exposure to …

Autoinflammatory diseases (AIDs) are a relatively new family of disorders, defined about 19
years ago. Some of them are hereditary and some are not. The names given to these …

Patients with autoinflammatory diseases present with noninfectious fever flares and systemic
and/or disease-specific organ inflammation. Their excessive proinflammatory cytokine and …