Cancer remains a leading cause of death worldwide, despite many advances being made in
recent decades. Changes in the tumor microenvironment, including dysregulated immunity …

Background: Leukotrienes are powerful mediators of inflammation and interact with specific
receptors in target cell membrane to initiate an inflammatory response. Thus, Leukotrienes …

Cancer cells grown in 3D spheroid cultures are considered more predictive for clinical
efficacy. The marine natural product dragmacidin D induces apoptosis in MDA-MB-231 and …

Background Breast cancer is usually associated with metastatic features, poor prognosis,
and high mortality. The epithelial-mesenchymal transition (EMT) process has been …

Aim Cysteinyl leukotrienes receptor antagonists (LTRAs) are promising chemoprevention
options to target cysteinyl leukotriene signaling in cancer. However, only a number of …

Mutations in the Von Hippel–Lindau (VHL) gene are the driving force in many forms of clear
cell renal cell carcinoma (ccRCC) and promote hypoxia-inducible factor (HIF)-dependent …

Montelukast sodium (MS) as an anti‐inflammatory agent in asthma requires a drug delivery
system to sustain release at specific doses. ZIF‐8 commonly used in drug delivery systems …

Montelukast and zafirlukast, cysteinyl leukotriene receptor antagonists (LTRAs), trigger
apoptosis and inhibit cell proliferation of triple-negative breast cancer MDA-MB-231 cells. By …

Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype, with a poor
survival rate compared to others subtypes. For a long time, chemotherapy was the only …

Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults.
Although rare, it is a deadly tumor, with a long-term prognosis of death occurring in more …