The BCL6 corepressor (BCOR) is a transcription factor involved in the control of
embryogenesis, mesenchymal stem cells function, hematopoiesis, and lymphoid …

Individuals with germ line variants associated with hereditary hematopoietic malignancies
(HHMs) have a highly variable risk for leukemogenesis. Gaps in our understanding of …

The treatment of acute myeloid leukemia (AML) with adverse genetics remains
unsatisfactory, with very low response rates to standard chemotherapy and shorter durations …

Germline pathogenic variants in DNMT3A were recently described in patients with
overgrowth, obesity, behavioral, and learning difficulties (D NMT3A O vergrowth S …

Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational
spectrum, lack of preclinical models, and poor prognosis. Here, using multiplexed genome …

Acute myeloid leukemia (AML) is a phenotypically and genetically heterogeneous
hematologic malignancy. Extensive sequencing efforts have mapped the genomic …

Simple Summary Acute myeloid leukemia (AML) is a genetically heterogeneous disease.
Clinical phenotypes of frequent mutations and their impact on patient outcome are well …

The occurrence of autophagy dysregulation is vital in the development of myelodysplastic
syndrome and its transformation to acute myeloid leukemia. However, the mechanisms are …

The clinical impact of therapy-related acute leukemias is increasing with the extension of
cancer-related survival; however, the origins remain largely unknown. Acute …

Malignancies of the erythroid lineage are rare but aggressive diseases. Notably, the first
insights into their biology emerged over half a century ago from avian and murine tumor …