Pharmacokinetics, pharmacodynamics, and therapeutic activity of drugs are defined by the
affinities between the drug and biological macromolecules through molecular recognition …

The utilization of BRAF and MEK inhibitors in combination therapy has demonstrated
superior outcomes in the treatment of melanoma as compared to monotherapy. In the …

Phytocompounds possess the potential to treat a broad spectrum of disorders due to their
remarkable bioactivity. Naturally occurring compounds possess lower toxicity profiles, which …

Hydroxychloroquine (HCQ), a quinoline based medicine is commonly used to treat malaria
and autoimmune diseases such as rheumatoid arthritis. Since, human serum albumin (HSA) …

The main protease (M pro) of the novel coronavirus SARS-CoV-2 is a key target for
developing antiviral drugs. Ebselen (EbSe) is a selenium-containing compound that has …

The COVID-19 disease is a major problem affecting human health all over the world.
Consequently, researchers have been trying to find solutions to treat this pandemic-scale …

Glioblastoma (GBM) is one of the most aggressive primary malignant brain tumors. The
major challenge is the lack of effective therapeutic drugs due to the blood–brain barrier …

The molecular docking calculations have been employed to investigate the interactions a set
of proteins with the repurposed anti-COVID drugs. The position of the therapeutic agents …

The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor
integral to various physiological and pathological processes. Among its diverse ligands …

Background Pregnant people with coronavirus disease 2019 (COVID-19) experience higher
risk for severe disease and adverse pregnancy outcomes, but no pharmacokinetic (PK) data …