Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

The development of the human brain involves unique processes (not observed in many
other species) that can contribute to neurodevelopmental disorders,,–. Cerebral organoids …

Summary Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling
complexes are multi-subunit molecular machines that play vital roles in regulating genomic …

The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …

DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

Chromatin remodeling is an essential cellular process for organizing chromatin structure into
either open or close configuration at specific chromatin locations by orchestrating and …

Abstract The mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4
is frequently mutated in cancer and inactivation results in a cellular dependence on its …