Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Gut microbiota is a potent biological modulator of many physiological and pathological
states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI …

Inflammatory bowel diseases (IBD) can be broadly divided into Crohn's disease (CD) and
ulcerative colitis (UC) from their clinical phenotypes. Over 150 host susceptibility genes have …

Dysbiosis is a hallmark of inflammatory bowel disease (IBD), but it is unclear which specific
intestinal bacteria predispose to and which protect from IBD and how they are regulated …

Objective The commensal microbiota, host immunity and metabolism participate in a
signalling network, with diet influencing each component of this triad. In addition to diet …

Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative
colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Genomic technologies inform the complex genetic basis of polygenic inflammatory bowel
disease (IBD) as well as Mendelian disease-associated IBD. Aiming to diagnose patients …

Congenital sodium diarrhea (CSD) refers to an intractable diarrhea of intrauterine onset with
high fecal sodium loss. CSD is clinically and genetically heterogeneous. Syndromic CSD is …

Marker gene amplicon sequencing is often preferred over whole genome sequencing for
microbial community characterization, due to its lower cost while still enabling assessment of …