Accumulation of DNA damage has been linked to the process of aging and to the onset of
age-related diseases including diabetes. Studies on progeroid syndromes have suggested …

Malignant disease occurs when neoplastic cells abandon their primary site of accretion,
cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process …

The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic
and invasive and, unlike most tumor models, can spontaneously metastasize from the …

In Drosophila, plexin A is a functional receptor for semaphorin-1a. Here we show that the
human plexin gene family comprises at least nine members in four subfamilies. Plexin-B1 is …

Studies on signal transduction pathways have generated various promising molecular
targets for therapeutic inhibition in cancer therapy. Receptor tyrosine kinases represent an …

Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …

Semaphorins are secreted or transmembrane proteins that regulate cell motility and
attachment in axon guidance, vascular growth, immune cell regulation and tumour …

Purpose: Perineural invasion is the only interaction between cancer cells and nerves
studied to date. It is a symbiotic relationship between cancer and nerves that results in …

Semaphorins are cell surface and soluble signals that control axonal guidance,. Recently,
semaphorin receptors (plexins) have been discovered and shown to be widely expressed …

Semaphorins are a large family of secreted or cell-bound signals, known to guide axons in
developing nervous tissue. They are expressed in a variety of adult and embryonic tissues …