Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”,
referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

▪ Abstract The author describes studies that led to the resolution and reconstitution of the
cytochrome P450 enzyme system in microsomal membranes. The review indicates how …

This book covers the relevant aspects of cytochromes P450 for understanding their structure,
function and mechanisms of action, such as physicochemical characterization methods …

The xenobiotic metabolizing cytochromes P450 (P450s) are among the most versatile
biological catalysts known, but knowledge of the structural basis for their broad substrate …

To date, the crystal structures of at least 12 human CYPs (1A2, 2A6, 2A13, 2C8, 2C9, 2D6,
2E1, 2R1, 3A4, 7A1, 8A1, and 46A1) have been determined. CYP2D6 accounts for only a …

The overproduction or underproduction of nitric oxide has been implicated in pathological
symptoms such as endotoxic shock, diabetes, allograft rejection, and myocardial …

This review continues a general presentation of the metabolism of drugs and other
xenobiotics started in a recent issue of Chemistry & Biodiversity. This Part 2 presents the …

We report evidence for the existence of distinct active oxidizing species in a cytochrome P-
450 model system. Competitive oxidations of alkane substrates were carried out using [5 …