Cancer cells have a unique energy metabolism for sustaining rapid proliferation. The
preference for anaerobic glycolysis under normal oxygen conditions is a unique trait of …

The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

The efficacy of immunotherapy is limited by the paucity of T cells delivered and infiltrated into
the tumors through aberrant tumor vasculature. Here, we report that phosphoglycerate …

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA
sequencing profiles tumors more comprehensively. Here this" proteogenomics" approach …

Highlights•NAMPT is overexpressed in cancers, associating with a poor prognosis and
tumor progression.•Extensive efforts have been made to improve efficacy and safety of early …

The de novo serine synthesis pathway is upregulated in many cancers. However, even
cancer cells with increased serine synthesis take up large amounts of serine from the …

Succinate dehydrogenase (SDH) is the mitochondrial enzyme converting succinate to
fumarate in the tricarboxylic acid (TCA) cycle. SDH acts as a tumor suppressor with germline …

Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an
increased reliance on NAD+ production pathways. This dependence may be exploited …

Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …

The serine glycine and one-carbon pathway (SGOCP) is a crucially important metabolic
network for tumorigenesis, of unanticipated complexity, and with implications in the clinic …