Protein kinase A (PKA) is a central regulator of cardiac performance and morphology.
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …

Cryogenic electron microscopy (cryo-EM) data represent density maps of macromolecular
systems at atomic or near-atomic resolution. However, building and refining 3D atomic …

Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …

Mammalian cyclic nucleotide-gated (CNG) channels play an essential role in the signal
transduction of the visual and olfactory sensory systems. Here we reveal the structural …

Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the
voltage-gated K+ channel superfamily that play crucial roles in many physiological …

In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed
of three CNGA and one CNGB subunits, and it closes in response to light activation to …

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels are both voltage-
and ligand-activated membrane proteins that contribute to electrical excitability and pace …

Cyclic nucleotide–gated (CNG) channels convert cyclic nucleotide (CN) binding and
unbinding into electrical signals in sensory receptors and neurons. The molecular …

Cyclic nucleotide-gated (CNG) ion channels are essential components of mammalian visual
and olfactory signal transduction. CNG channels open upon direct binding of cyclic …

Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal
transduction. The free energy difference of cyclic-nucleotide (cAMP/cGMP) …