Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways

T Darville - The Journal of infectious diseases, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) results from ascension of sexually transmitted pathogens
from the lower genital tract to the uterus and/or fallopian tubes in women, with potential …

Management of pelvic inflammatory disease in clinical practice

H Yusuf, M Trent - Therapeutics and Clinical Risk Management, 2023 - Taylor & Francis
Pelvic inflammatory disease (PID) is a common reproductive health disorder among women
of reproductive age. The treatment of PID has slowly evolved, reflecting changing antibiotic …

Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

C Yang, L Lei, JWM Collins, M Briones, L Ma… - Nature …, 2021 - nature.com
Chlamydia trachomatis infection causes severe inflammatory disease resulting in blindness
and infertility. The pathophysiology of these diseases remains elusive but myeloid cell …

Advances in vaccine development for Chlamydia trachomatis

TB Poston - Pathogens and Disease, 2024 - academic.oup.com
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection globally.
Antibiotic treatment is highly effective, but infection is often asymptomatic resulting in most …

Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine

S Shetty, C Kouskouti, U Schoen… - Brazilian Journal of …, 2021 - Springer
Purpose Chlamydial genital infections constitute significant sexually transmitted infections
worldwide. The often asymptomatic status of C. trachomatis (CT) infections leads to an …

Translational bioinformatics for human reproductive biology research: examples, opportunities and challenges for a future reproductive medicine

K Liu, Y Zhang, C Martin, X Ma, B Shen - International Journal of …, 2022 - mdpi.com
Since 1978, with the first IVF (in vitro fertilization) baby birth in Manchester (England), more
than eight million IVF babies have been born throughout the world, and many new …

Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection

TB Poston, DAE Lee, T Darville, W Zhong… - The Journal of …, 2019 - academic.oup.com
Background Chlamydia trachomatis can cause reproductive morbidities after ascending to
the upper genital tract of women, and repeated infection can lead to worse disease. Data …

Inhibition of TLR2/TLR4 alleviates the Neisseria gonorrhoeae infection damage in human endometrial epithelial cells via Nrf2 and NF-Kβsignaling

Y Yang, S Liu, J Liu, N Ta - Journal of Reproductive Immunology, 2020 - Elsevier
Abstract Background Neisseria gonorrhoeae (Ng) is Gram-negative bacteria and can lead to
endometritis in female. Toll-like receptors regulate immune response in various diseases …

Chlamydia trachomatis plasmid gene protein 3 is essential for the establishment of persistent infection and associated immunopathology

C Yang, L Kari, L Lei, JH Carlson, L Ma, CE Couch… - MBio, 2020 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding
trachoma and sexually transmitted disease afflicting hundreds of millions of people globally …

Impact of Human Genetic Variation on C-Reactive Protein Concentrations and Acute Appendicitis

I Ricaño-Ponce, T Peeters, V Matzaraki… - Frontiers in …, 2022 - frontiersin.org
Background Acute appendicitis is one of the most common abdominal emergencies
worldwide. Both environmental and genetic factors contribute to the disease. C-reactive …