Open questions in the social lives of viruses
Social interactions among viruses occur whenever multiple viral genomes infect the same
cells, hosts, or populations of hosts. Viral social interactions range from cooperation to …
cells, hosts, or populations of hosts. Viral social interactions range from cooperation to …
Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies
IM Rouzine, G Rozhnova - Communications medicine, 2023 - nature.com
Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar
of the public health response to the COVID-19 pandemic. It was very effective in reducing …
of the public health response to the COVID-19 pandemic. It was very effective in reducing …
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …
and effectively evaded immune responses, its viral fitness in cell and animal models was …
Evolution of naturally arising SARS-CoV-2 defective interfering particles
S Girgis, Z Xu, S Oikonomopoulos… - Communications …, 2022 - nature.com
Defective interfering (DI) particles arise during virus propagation, are conditional on parental
virus for replication and packaging, and interfere with viral expansion. There is much interest …
virus for replication and packaging, and interfere with viral expansion. There is much interest …
Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer …
COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer …
Virus-like particles: Measures and biological functions
Virus-like particles resemble infectious virus particles in size, shape, and molecular
composition; however, they fail to productively infect host cells. Historically, the presence of …
composition; however, they fail to productively infect host cells. Historically, the presence of …
Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection
Defective viral genomes (DVGs) have been identified in many RNA viruses as a major factor
influencing antiviral immune response and viral pathogenesis. However, the generation and …
influencing antiviral immune response and viral pathogenesis. However, the generation and …
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters
The high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe …
is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe …
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome
Productive infections by RNA viruses require faithful replication of the entire genome. Yet
many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant …
many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant …