[HTML][HTML] CRISPR/Cas9 genome editing for neurodegenerative diseases

JN Nojadeh, NSB Eryilmaz, Bİ Ergüder - EXCLI journal, 2023 - ncbi.nlm.nih.gov
Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The …

[HTML][HTML] Advances in nanoparticles as non-viral vectors for efficient delivery of CRISPR/Cas9

M Kim, Y Hwang, S Lim, HK Jang, HO Kim - Pharmaceutics, 2024 - pmc.ncbi.nlm.nih.gov
The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system is a
gene-editing technology. Nanoparticle delivery systems have attracted attention because of …

[HTML][HTML] CRISPR/Cas9 systems: delivery technologies and biomedical applications

Y Du, Y Liu, J Hu, X Peng, Z Liu - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
The emergence of the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a …

Putting CRISPR-Cas system in action: a golden window for efficient and precise genome editing for crop improvement

A Tariq, M Mushtaq, H Yaqoob, BA Bhat… - GM Crops & …, 2023 - Taylor & Francis
The daunting task of feeding an ever-growing population is an immense challenge for the
contemporary scientific community, especially in view of the rapidly changing climate …

Role of CRISPR/Cas9 in the treatment of Duchenne muscular dystrophy and its delivery strategies

P Agrawal, V Harish, S Mohd, SK Singh, D Tewari… - Life Sciences, 2023 - Elsevier
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder brought on by mutations
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …

Leveraging QM/MM and Molecular Dynamics Simulations to Decipher the Reaction Mechanism of the Cas9 HNH Domain to Investigate Off-Target Effects

Y Maghsoud, VM Jayasinghe-Arachchige… - Journal of Chemical …, 2023 - ACS Publications
The clustered regularly interspaced short palindromic repeats (CRISPR) technology is an
RNA-guided targeted genome-editing tool using Cas family proteins. Two magnesium …

[HTML][HTML] Unity among the diverse RNA-guided CRISPR-Cas interference mechanisms

C Ganguly, S Rostami, K Long, SD Aribam… - Journal of Biological …, 2024 - Elsevier
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-
associated) systems are adaptive immune systems that protect bacteria and archaea from …

A DNA unwinding equilibrium serves as a checkpoint for CRISPR-Cas12a target discrimination

J Singh, KG Liu, A Allen, W Jiang… - Nucleic Acids …, 2023 - academic.oup.com
CRISPR-associated proteins such as Cas9 and Cas12a are programable RNA-guided
nucleases that have emerged as powerful tools for genome manipulation and molecular …

Exploring CRISPR-Cas9 HNH-Domain-Catalyzed DNA Cleavage Using Accelerated Quantum Mechanical Molecular Mechanical Free Energy Simulation

R Van, X Pan, S Rostami, J Liu, PK Agarwal… - Biochemistry, 2024 - ACS Publications
The target DNA (tDNA) cleavage catalyzed by the CRISPR Cas9 enzyme is a critical step in
the Cas9-based genome editing technologies. Previously, the tDNA cleavage from an active …

Актуальные проблемы биоэкономики, роль постгеномных дисциплин

ЕС Титова, СС Шишкин - 2023 - elibrary.ru
В монографии обобщены современные представления о формировании и развитии
биоэкономики, что было обусловлено использованием крупных достижений наук о …