Pathogenicity and virulence of Clostridium botulinum

AM Rawson, AW Dempster, CM Humphreys… - Virulence, 2023 - Taylor & Francis
Clostridium botulinum, a polyphyletic Gram-positive taxon of bacteria, is classified purely by
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …

Public health risk associated with botulism as foodborne zoonoses

C Rasetti-Escargueil, E Lemichez, MR Popoff - Toxins, 2019 - mdpi.com
Botulism is a rare but severe neurological disease in man and animals that is caused by
botulinum neurotoxins (BoNTs) produced by Clostridium botulinum and atypical strains from …

Novel botulinum neurotoxins: Exploring underneath the iceberg tip

DA Tehran, M Pirazzini - Toxins, 2018 - mdpi.com
Botulinum neurotoxins (BoNTs), the etiological agents of botulism, are the deadliest toxins
known to humans. Yet, thanks to their biological and toxicological features, BoNTs have …

Why are botulinum neurotoxin-producing bacteria so diverse and botulinum neurotoxins so toxic?

B Poulain, MR Popoff - Toxins, 2019 - mdpi.com
Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant
and chemical poisonous compounds. Although a great effort has been made to understand …

Botulinum neurotoxin detection methods for public health response and surveillance

N Thirunavukkarasu, E Johnson, S Pillai… - … in bioengineering and …, 2018 - frontiersin.org
Botulism outbreak due to consumption of food contaminated with botulinum neurotoxins
(BoNTs) is a public health emergency. The threat of bioterrorism through deliberate …

Human botulism in France, 1875–2016

C Rasetti-Escargueil, E Lemichez, MR Popoff - Toxins, 2020 - mdpi.com
Botulism is a rare but severe disease which is characterized by paralysis and inhibition of
secretions. Only a few cases had been reported at the end of the 19th century in France. The …

Discovery of novel bacterial toxins by genomics and computational biology

AC Doxey, MJ Mansfield, C Montecucco - Toxicon, 2018 - Elsevier
Hundreds and hundreds of bacterial protein toxins are presently known. Traditionally, toxin
identification begins with pathological studies of bacterial infectious disease. Following …

Neuronal selectivity of botulinum neurotoxins

B Poulain, E Lemichez, MR Popoff - Toxicon, 2020 - Elsevier
Botulinum neurotoxins (BoNTs) are highly potent toxins responsible for a severe disease,
called botulism. They are also efficient therapeutic tools with an increasing number of …

Clostridium botulinum and Clostridium perfringens Occurrence in Kazakh Honey Samples

B Maikanov, R Mustafina, L Auteleyeva, J Wiśniewski… - Toxins, 2019 - mdpi.com
The aim of this study was to assess occurrence of Clostridium botulinum and Clostridium
perfringens in honey samples from Kazakhstan. Analyses were carried out using a set of …

Toxemia in human naturally acquired botulism

C Rasetti-Escargueil, E Lemichez, MR Popoff - Toxins, 2020 - mdpi.com
Human botulism is a severe disease characterized by flaccid paralysis and inhibition of
certain gland secretions, notably salivary secretions, caused by inhibition of neurotransmitter …