[HTML][HTML] Anti-inflammatory herbal extracts and their drug discovery perspective in atopic dermatitis

JW Lee, EN Kim, GS Jeong - Biomolecules & Therapeutics, 2024 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well
known that the activation of various inflammatory cells and the generation of inflammatory …

An emerging role of endometrial inflammasome in reproduction: new therapeutic approaches

F Di Nicuolo, M Specchia, L Trentavizi… - Protein and Peptide …, 2018 - ingentaconnect.com
Background: One of the common complications of pregnancy is spontaneous pregnancy
loss which occurs in an estimated 5-15% of pregnancies. Of all women 1%-5% suffer from …

A TCM formula VYAC ameliorates DNCB-induced atopic dermatitis via blocking mast cell degranulation and suppressing NF-κB pathway

HR Zeng, B Zhao, X Rui, GH Jia, Y Wu, D Zhang… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance A Traditional Chinese Medicine (TCM) formula
(VYAC) consists of three herbs including Viola yedoensis Makino, herb (Violaceae, Viola) …

[HTML][HTML] Dasatinib inhibits Lyn and Fyn Src-family kinases in mast cells to suppress type I hypersensitivity in mice

D Lee, YH Park, JE Lee, HS Kim, KY Min… - Biomolecules & …, 2020 - ncbi.nlm.nih.gov
Mast cells (MCs) are systemically distributed and secrete several allergic mediators such as
histamine and leukotrienes to cause type I hypersensitivity. Dasatinib is a type of anti-cancer …

Anti-inflammatory activity of mulberrofuran K isolated from the bark of Morus bombycis

SY Shim, SH Sung, M Lee - International Immunopharmacology, 2018 - Elsevier
Morus bombycis Koidzumi, commonly known as silkworm mulberry, is a plant belonging to
family Moraceae. It has been used in Asian countries as a traditional medicine for treating …

Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn …

YH Park, DK Kim, HW Kim, HS Kim, D Lee… - Biochemical …, 2018 - Elsevier
Mast cells are critical effector cells in IgE-mediated allergic responses. The aim of this study
was to investigate the anti-allergic effects of 3-[(aminocarbonyl) amino]-5-(3-fluorophenyl)-N …

CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation

YB Hou, K Ji, YT Sun, LN Zhang, JJ Chen - Journal of Translational …, 2019 - Springer
Background Mast cell activation causes degranulation and release of cytokines, thereby
promoting inflammation. The aim of this study was to investigate the inhibitory effect of …

Natural compounds against allergic and pseudoallergic reactions: Molecular mechanisms of action

J Castillo-Arellano, C González-Espinosa… - Studies in Natural …, 2024 - Elsevier
Allergic diseases such as allergic rhinitis, asthma, food allergies, and atopic dermatitis may
affect up to 20% of the population worldwide, with increasing prevalence rates. Mast cells …

Protective effect of Achyranthes aspera against compound 48/80, histamine and ovalbumin-induced allergic disorders in murine model

A Kaushik, DP Singh, M Sahu, A Kumar… - Molecular Biology …, 2024 - Springer
Background Achyranthes aspera L.(family Amaranthaceae) is a plant species valued in
Ayurveda for the treatment of respiratory ailments. Scientific validation of its antiallergic …

The antipsychotic drug pimozide inhibits IgE-mediated mast cell degranulation and migration

YB Hou, LN Zhang, HN Wang, ZF Zhao, YT Sun… - International …, 2020 - Elsevier
Abstract Background Mast cells (MCs) mediate a key role in allergic diseases. Detailed
studies of how the neuroleptic drug pimozide affects MC activity are lacking. The aim of this …