Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19
Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
Targeting the brain reservoirs: toward an HIV cure
C Marban, F Forouzanfar, A Ait-Ammar… - Frontiers in …, 2016 - frontiersin.org
One of the top research priorities of the international AIDS society by the action “Towards an
HIV Cure” is the purge or the decrease of the pool of all latently infected cells. This strategy …
HIV Cure” is the purge or the decrease of the pool of all latently infected cells. This strategy …
The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era
V Chilunda, TM Calderon, P Martinez-Aguado… - Brain research, 2019 - Elsevier
Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …
(HIV). One highly significant complication of HIV infection is the development of HIV …
Transcriptomic and clonal characterization of T cells in the human central nervous system
JL Pappalardo, L Zhang, MK Pecsok, K Perlman… - Science …, 2020 - science.org
T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …
Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection
CB Sturdevant, SB Joseph, G Schnell, RW Price… - PLoS …, 2015 - journals.plos.org
Compartmentalized HIV-1 replication within the central nervous system (CNS) likely
provides a foundation for neurocognitive impairment and a potentially important tissue …
provides a foundation for neurocognitive impairment and a potentially important tissue …
Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance
S Spudich, KR Robertson, RJ Bosch… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND Persistence of HIV in sanctuary sites despite antiretroviral therapy (ART)
presents a barrier to HIV remission and may affect neurocognitive function. We assessed …
presents a barrier to HIV remission and may affect neurocognitive function. We assessed …
Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury
Antiretroviral therapy (ART) can attain prolonged undetectable HIV-1 in plasma and
cerebrospinal fluid (CSF), but brain injury remains prevalent in people living with HIV-1 …
cerebrospinal fluid (CSF), but brain injury remains prevalent in people living with HIV-1 …
[HTML][HTML] HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART
People with HIV (PWH) on antiretroviral therapy (ART) experience elevated rates of
neurological impairment, despite controlling for demographic factors and comorbidities …
neurological impairment, despite controlling for demographic factors and comorbidities …
[HTML][HTML] Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV
SF Farhadian, SS Mehta, C Zografou, K Robertson… - JCI insight, 2018 - ncbi.nlm.nih.gov
Central nervous system (CNS) immune activation is an important driver of neuronal injury
during several neurodegenerative and neuroinflammatory diseases. During HIV infection …
during several neurodegenerative and neuroinflammatory diseases. During HIV infection …
Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection
J Peterson, M Gisslen, H Zetterberg, D Fuchs… - PloS one, 2014 - journals.plos.org
The character of central nervous system (CNS) HIV infection and its effects on neuronal
integrity vary with evolving systemic infection. Using a cross-sectional design and archived …
integrity vary with evolving systemic infection. Using a cross-sectional design and archived …