Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

[HTML][HTML] Ionizing radiation-induced circulatory and metabolic diseases

S Tapio, MP Little, JC Kaiser, N Impens… - Environment …, 2021 - Elsevier
Risks to health are the prime consideration in all human situations of ionizing radiation
exposure and therefore of relevance to radiation protection in all occupational, medical, and …

Heart in space: effect of the extraterrestrial environment on the cardiovascular system

RL Hughson, A Helm, M Durante - Nature Reviews Cardiology, 2018 - nature.com
National space agencies and private corporations aim at an extended presence of humans
in space in the medium to long term. Together with currently suboptimal technology …

Human health during space travel: state-of-the-art review

C Krittanawong, NK Singh, RA Scheuring, E Urquieta… - Cells, 2022 - mdpi.com
The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Apollo lunar astronauts show higher cardiovascular disease mortality: possible deep space radiation effects on the vascular endothelium

MD Delp, JM Charvat, CL Limoli, RK Globus… - Scientific reports, 2016 - nature.com
As multiple spacefaring nations contemplate extended manned missions to Mars and the
Moon, health risks could be elevated as travel goes beyond the Earth's protective …

Effects of ionizing radiation on the heart

M Boerma, V Sridharan, XW Mao, GA Nelson… - … Research/Reviews in …, 2016 - Elsevier
This article provides an overview of studies addressing effects of ionizing radiation on the
heart. Clinical studies have identified early and late manifestations of radiation-induced …

Cardiovascular disease in space: A systematic review

C Krittanawong, A Isath, S Kaplin, HUH Virk… - Progress in …, 2023 - Elsevier
Background With expanding commercial space programs, uncertainty remains about the
cardiovascular effects of space environmental exposures including microgravity …

[HTML][HTML] The effects of microgravity and space radiation on cardiovascular health: From low-Earth orbit and beyond

S Patel - IJC Heart & Vasculature, 2020 - Elsevier
The unique conditions of space harbor considerable challenges for astronauts to overcome.
Namely, the ionizing content of space radiation and the effects of microgravity have been …

Leveraging spaceflight to advance cardiovascular research on earth

JM Scott, J Stoudemire, L Dolan, M Downs - Circulation research, 2022 - Am Heart Assoc
The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of
spaceflight extend across multiple systems resulting in whole-organism cardiovascular …

Myocardial disease and long-distance space travel: Solving the radiation problem

M Meerman, TCL Bracco Gartner… - Frontiers in …, 2021 - frontiersin.org
Radiation-induced cardiovascular disease is a well-known complication of radiation
exposure. Over the last few years, planning for deep space missions has increased interest …