Tubulin and microtubules are subject to a remarkable number of post-translational
modifications. Understanding the roles these modifications play in determining the functions …

Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Microtubules are cytoskeletal polymers with two structurally and functionally distinct ends,
the plus-and the minus-end. Here, we focus on the mechanisms underlying the regulation of …

Here we introduce plusTipTracker, a Matlab-based open source software package that
combines automated tracking, data analysis, and visualization tools for movies of …

The expansion of the neocortex during mammalian brain evolution results primarily from an
increase in neural progenitor cell divisions in its two principal germinal zones during …

The function of microtubules depends on their arrangement into highly ordered arrays.
Spatio-temporal control over the formation of new microtubules and regulation of their …

Polarized epithelial cells exhibit a characteristic array of microtubules that are oriented along
the apicobasal axis of the cells. The minus-ends of these microtubules face apically, and the …

Tau is a microtubule (MT)-stabilizing protein that is altered in Alzheimer's disease (AD) and
other tauopathies. It is hypothesized that the hyperphosphorylated, conformationally altered …

The regulation of microtubule dynamics is critical to ensure essential cell functions, such as
proper segregation of chromosomes during mitosis or cell polarity and migration. End …

Nearly every cell type exhibits some form of polarity, yet the molecular mechanisms vary
widely. Here we examine what we term 'chemical systems' where cell polarization arises …