[HTML][HTML] The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges

EJ Kuijer, L Steenbergen - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
A fundamental shift in neuroscience suggests bidirectional interaction of gut microbiota with
the healthy and dysfunctional brain. This microbiota-gut-brain axis has mainly been …

Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases

J Liu, H Zhang, Y Su, B Zhang - Cell & bioscience, 2022 - Springer
Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive
inflammation are responsible for the occurrence and development of autoimmune diseases …

CD8+ T cells contribute to diet-induced memory deficits in aged male rats

MJ Butler, S Sengupta, SM Muscat, SA Amici… - Brain, behavior, and …, 2023 - Elsevier
We have previously shown that short-term (3-day) high fat diet (HFD) consumption induces a
neuroinflammatory response and subsequent impairment of long-term memory in aged, but …

Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates

MJ Butler, NP Deems, S Muscat, CM Butt… - Brain, behavior, and …, 2021 - Elsevier
The consumption of a processed foods diet (PD) enriched with refined carbohydrates,
saturated fats, and lack of fiber has increased in recent decades and likely contributed to …

Resveratrol can attenuate astrocyte activation to treat spinal cord injury by inhibiting inflammatory responses

R Fan, Y Zhang, BOA Botchway, X Liu - Molecular Neurobiology, 2021 - Springer
Several preclinical and clinical studies have attempted to elucidate the pathophysiological
mechanism associated with spinal cord injury. However, investigations have been unable to …

[HTML][HTML] Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension …

CY Ho, GC Sun, YT Lin, TY Wong, M Hsiao… - European Journal of …, 2024 - Elsevier
Our previous study reported that the heterodimer of Angiotensin II Type I Receptor (AT1R)
and Mu-Opioid Receptor 1 (MOR1) involves Nitric Oxide (NO) reduction which leads to …

Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia

H Naik, E Cooke, T Boulter, R Dyer, JN Bone, M Tsai… - BMJ open, 2024 - bmjopen.bmj.com
Introduction A significant proportion of individuals suffering from post COVID-19 condition
(PCC, also known as long COVID) can present with persistent, disabling fatigue similar to …

A behavioral and molecular study; ameliorated anxiety‐like behavior and cognitive dysfunction in a rat model of chronic unpredictable stress treated with oregano …

P Mohseni‐Moghaddam, M Dogani… - Brain and …, 2022 - Wiley Online Library
Objective Chronic stress is considered a severe risk factor leading to various disorders,
including anxiety and cognitive decline. The present study aimed to investigate the effects of …

Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain

AJ Kwilasz, SMG Fulgham, JC Duran-Malle… - Brain, behavior, and …, 2021 - Elsevier
Neuropathic pain is a major symptom of multiple sclerosis (MS) with up to 92% of patients
reporting bodily pain, and 85% reporting pain severe enough to cause functional disability …

Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis

AJ Kwilasz, MA Clements, TA Larson… - Frontiers in Pain …, 2022 - frontiersin.org
Up to 92% of patients suffering from multiple sclerosis (MS) experience pain, most without
adequate treatment, and many report pain long before motor symptoms associated with MS …