Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

The increasing concerns toward the quality and health of food products have necessitated
accurate and precise analytical methods in order to guarantee the quality of food. It is …

The adenosine A2B receptor is the least well characterized of the four known adenosine
receptor subtypes because of the absence of potent, selective agonists. Here, we present …

Abstract The A 1, A 2A, A 2B and A 3 G-protein-coupled cell surface adenosine receptors
(ARs) are found to be upregulated in various tumor cells. Activation of the receptors by …

Ever since the discovery of the hypotensive and bradycardiac effects of adenosine,
adenosine receptors continue to represent promising drug targets. First, this is due to the fact …

Interest in adenosine deaminase (ADA) in the context of medicine has mainly focused on its
enzymatic activity. This is justified by the importance of the reaction catalyzed by ADA not …

Here we report the synthesis of 8-heterocycle-substituted xanthines as potent and selective
A2B adenosine receptor antagonists. The structure− activity relationships (SAR) of the …

Adenosine receptor antagonists usually possess a bi-or tricyclic heteroaromatic structure at
their core with varying substitution patterns to achieve selectivity and/or greater affinity …

Adenosine receptors belong to the family of G protein-coupled receptors. Four distinct
subtypes are known, termed A1, A2A, A2B and A3. Adenosine is an important signaling …

A new series of N6-[(hetero) aryl/(cyclo) alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-
ethylcarboxamido-adenosines (24–43) has been synthesised and tested in binding assays …