Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

The turnover of the intestinal epithelium is driven by multipotent LGR5+ crypt-base columnar
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …