[HTML][HTML] The synthetic and therapeutic expedition of isoxazole and its analogs

N Agrawal, P Mishra - Medicinal Chemistry Research, 2018 - Springer
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …

Oxazole and isoxazole: From one-pot synthesis to medical applications

A Thakur, M Verma, R Bharti, R Sharma - Tetrahedron, 2022 - Elsevier
N, O-containing five-membered heterocycles especially oxazole and isoxazole, have widely
been found in many natural products and drugs with relevant medicinal and pharmaceutical …

[HTML][HTML] An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold

S Das, K Chanda - RSC advances, 2021 - pubs.rsc.org
In the field of drug discovery, isoxazole is a five-membered heterocyclic moiety commonly
found in many commercially available drugs. In view of their enormous significance, it is …

The Isoxazole Ring and Its N‐Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics

GN Pairas, F Perperopoulou, PG Tsoungas… - …, 2017 - Wiley Online Library
Mental disorders are neuropsychiatric conditions that are marked by unusual or irregular
thinking, feelings, or behavior, and lead to distress and/or impaired functions. Major …

Oxyboration with and without a catalyst: borylated isoxazoles via B–O σ-bond addition

KN Tu, JJ Hirner, SA Blum - Organic letters, 2016 - ACS Publications
Herein we report an oxyboration reaction with activated substrates that employs B–O σ bond
additions to C–C π bonds to form borylated isoxazoles, which are potential building blocks …

[HTML][HTML] Novel insights on acetylcholinesterase inhibition by Convolvuluspluricaulis, scopolamine and their combination in zebrafish

KB Karunakaran, A Thiyagaraj… - Natural Products and …, 2022 - Springer
Acetylcholinesterase (AChE) inhibitors increase the retention of acetylcholine (ACh) in
synapses. Although they alleviate cognitive deficits in Alzheimer's disease, their limited …

[HTML][HTML] Cholinesterase inhibitory activities of neuroprotective fraction derived from red alga Gracilaria manilaensis

JR Pang, SW How, KH Wong, SH Lim… - Fisheries and Aquatic …, 2022 - e-fas.org
Anti-cholinesterase (ChE) s are commonly prescribed as the symptomatic treatment of
Alzheimer's disease. They are applied to prevent the breakdown of neurotransmitter …

Remote Arylative Substitution of Alkenes Possessing an Acetoxy Group via β‐Acetoxy Elimination

K Muto, T Kumagai, F Kakiuchi, T Kochi - Angewandte Chemie, 2021 - Wiley Online Library
Palladium‐catalyzed remote arylative substitution was achieved for the reaction of
arylboronic acids with alkenes possessing a distant acetoxy group to provide arylation …

Novel N‐allyl/propargyl tetrahydroquinolines: Synthesis via Three‐component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as …

YA Rodríguez, M Gutiérrez, D Ramírez… - Chemical biology & …, 2016 - Wiley Online Library
New N‐allyl/propargyl 4‐substituted 1, 2, 3, 4‐tetrahydroquinolines derivatives were
efficiently synthesized using acid‐catalyzed three components cationic imino Diels–Alder …

[HTML][HTML] New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22phox-p47phox Interactions

AV Treuer, M Faúndez, R Ebensperger, E Hovelmeyer… - Antioxidants, 2023 - mdpi.com
NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in
neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular …