Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

Background Burning mouth syndrome is a chronic idiopathic intractable intraoral
dysaesthesia that remains a challenge to clinicians due to its poorly understood …

The role of melatonin has been extensively investigated in pathophysiological conditions,
including autism spectrum disorder (ASD). Reduced melatonin secretion has been reported …

Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin
has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative …

Oxygen is used by eukaryotic cells for metabolic transformations and energy production in
mitochondria. Under physiological conditions, there is a constant endogenous production of …

Background Fibromyalgia is a chronic widespread pain condition affecting millions of people
worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining …

Background Chronic pain is common in adults, and often has a detrimental impact upon
physical ability, well‐being, and quality of life. Previous reviews have shown that certain …

Introduction: Fibromyalgia is a syndrome characterized by chronic generalized pain in
addition to different symptoms such as fatigue, sleep disturbances, stiffness, cognitive …

Background Central disinhibition is a mechanism involved in the physiopathology of
fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We …

Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal
environment with the photoperiod. It is synthesized in the pineal gland and greatly depends …