Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Medication‐related osteonecrosis of the jaw: a literature review and update

S Kuroshima, FA Al‐Omari, M Sasaki, T Sawase - Genesis, 2022 - Wiley Online Library
Since the initial description of medication‐related osteonecrosis of the jaw (MRONJ) almost
two decades ago, the potential pathophysiology and risk factors have been elaborated on in …

Medication-Related Osteonecrosis: Why the Jawbone?

S Kuehn, R Scariot, M Elsalanty - Dentistry Journal, 2023 - mdpi.com
Medication-related osteonecrosis of the jaw (MRONJ) has emerged as a complication of anti-
resorptive medications. Despite its low incidence rate, this problem has gained attention in …

Pathophysiology of Medication‐Related Osteonecrosis of the Jaw—A Minireview

S Tetradis, MR Allen, SL Ruggiero - Journal of Bone and Mineral …, 2023 - academic.oup.com
Medication‐related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse effect of
antiresorptive medications administered for control of osseous malignancy, osteoporosis, or …

Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes

H Hadad, HR Matheus, SI Pai, FA Souza… - Archives of oral …, 2024 - Elsevier
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …

Association between periodontal disease, tooth extraction, and medication‐related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort …

MJ Kwoen, JH Park, KS Kim, JR Lee… - Journal of …, 2023 - Wiley Online Library
Background We investigated whether periodontal diseases contribute to the development of
medication‐related osteonecrosis of the jaw (MRONJ) in addition to tooth extraction, which …

Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

R Yan, R Jiang, L Hu, Y Deng, J Wen… - International journal of …, 2022 - nature.com
Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with
administering antiresorptive or antiangiogenic drugs. Despite significant research on …

Anti-resorptive therapy in the osteometabolic patient affected by periodontitis. A joint position paper of the Italian Society of Orthopaedics and Traumatology (SIOT) and …

L Landi, PT Leali, L Barbato, AM Carrassi… - Journal of Orthopaedics …, 2023 - Springer
This joint report from the Italian Society of Orthopaedics and Traumatology (SIOT) and the
Italian Society of Periodontology and Implantology (SIdP) aims for a consensus around the …

Chronic periodontal infection and not iatrogenic interference is the trigger of medication-related osteonecrosis of the jaw: insights from a large animal study …

M Troeltzsch, S Zeiter, D Arens, D Nehrbass, FA Probst… - Medicina, 2023 - mdpi.com
Background and Objectives: Antiresorptive drugs are widely used in osteology and
oncology. An important adverse effect of these drugs is medication-induced osteonecrosis of …

Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

H Okawa, T Kondo, A Hokugo, P Cherian… - Communications …, 2022 - nature.com
Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but serious
side effect of nitrogen-containing bisphosphonate drugs (N-BPs) frequently prescribed to …