Multidirectional interactions between metabolic organs in the periphery and the central
nervous system have evolved concomitantly with multicellular organisms to maintain whole …

The gastrointestinal tract can assess the nutrient composition of ingested food. The nutrient-
sensing mechanisms in specialised epithelial cells lining the gastrointestinal tract, the …

The molecular mediator and functional significance of meal-associated brown fat (BAT)
thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non …

Medical management of obesity represents a large unmet clinical need. Animal experiments
suggest a therapeutic potential for dietary capsaicin, the pungent ingredient in hot chili …

Metabolic diseases have been a major public health issue and a clinical challenge
worldwide. Dysfunction of metabolic homeostasis is linked to the onset of various diseases …

Mammalian neurons that produce oxytocin and vasopressin apparently evolved from an
ancient cell type with both sensory and neurosecretory properties that probably linked …

The number of people living with obesity has tripled worldwide since 1975 with serious
implications for public health, as obesity is linked to a significantly higher chance of early …

Modern scientific theories of emotional behavior, almost without exception, trace their origin
to Charles Darwin, and his publications On the Origin of Species (1859) and The Expression …

Secretin, though originally discovered as a gut-derived hormone, is recently found to be
abundantly expressed in the ventromedial hypothalamus, from which the central neural …

Since the discovery of functionally competent, energy-consuming brown adipose tissue
(BAT) in adult humans, much effort has been devoted to exploring this tissue as a means for …