Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Rho GTPases are molecular switches that regulate many essential cellular processes,
including actin dynamics, gene transcription, cell-cycle progression and cell adhesion …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

Signaling via growth factor receptors frequently results in the concomitant activation of
phospholipase Cγ (PLCγ) and phosphatidylinositol (PI) 3‐kinase. While it is well established …

▪ Abstract The actin cytoskeleton is a highly dynamic network composed of actin polymers
and a large variety of associated proteins. The main functions of the actin cytoskeleton are to …

Abstract The Rho GTPases mediate actin rearrangements that are likely to be required for
the numerous cell shape changes in a developing embryo. In a genetic screen for Rho …

The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by
catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The …

The Rho-related small GTPases are critical elements involved in regulation of signal
transduction cascades from extracellular stimuli to cell nucleus and cytoskeleton. The Dbl …