The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

Introduction H YPOPHYSECTOMIZED rats have a defect in the synthesis of matrix protein
which is rapidly repaired by the administration of GH in vivo. In 1957, it was first reported that …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

To examine the relationship between growth hormone (GH) and insulin-like growth factor 1
(IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

Poor postnatal growth after preterm birth does not match the normal rapid growth in utero
and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the …

Besides their growth-promoting properties, GH and IGF-1 regulate a broad spectrum of
biological functions in several organs, including the kidney. This review focuses on the renal …

▪ Abstract The traditionally accepted theory has been that most of the biological effects of
growth hormone (GH) are mediated by circulating (endocrine) insulin-like growth factor-I …

To ascertain if IGF-1 is a regulator of local muscle growth, total RNA was extracted from
rabbit muscle induced to undergo rapid hypertrophy using active stretch and from control …