Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …

Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

CD4+ CD25+ regulatory T (Treg) cells control immunologic tolerance and antitumor immune
responses. Therefore, in vivo modification of Treg function by immunosuppressant drugs has …

FOXP3 is playing an essential role for T regulatory cells and is involved in the molecular
mechanisms controlling immune tolerance. Although the biological relevance of this …

Previously, we have found that the absence of the colon after liver transplantation (LT)
protects the patient from recurrent primary sclerosing cholangitis (rPSC). As our previous …

Regulatory T cells (Tregs) play an important role in immunoregulation and have been shown
in animal models to promote transplantation tolerance and curb autoimmunity following their …

Background. Immunosuppression in renal transplantation, although manageable in the short-
term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4+ …

The outcome of T-cell-mediated responses, immunity or tolerance, critically depends on the
balance of cytopathic versus regulatory T (T reg) cells. In the creation of stable tolerance to …

Regulatory T cells (Tregs) are long-lived cells that suppress immune responses in vivo in a
dominant and antigen-specific manner. Therefore, therapeutic application of Tregs to control …

Background. Human liver allografts do sometimes survive in a recipient after withdrawal of
immunosuppression (IS), commonly referred to as “operational tolerance.” Preliminary …