Aspergillus is a ubiquitous ascomycete that can cause a variety of clinical presentations
depending on immune status. Central nervous system aspergillosis is a fatal disease with …

Central nervous system infections due to Aspergillus spp and other hyaline molds such as
Fusarium and Scedosporium spp are rare but fatal conditions. Invasion of the central …

Isavuconazole's (ISA) pharmacokinetics was studied among lung transplant recipients to
evaluate its bronchopulmonary penetration. This study included 13 patients and showed …

We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-
year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The …

The problem with cancer tissue is that its intratumoral heterogeneity and its complexity is
extremely high as cells possess, depending on their location and function, different …

Invasive aspergillosis (IA) is a major cause of morbidity and mortality in patients receiving
allogeneic haematopoieticcell transplantation. The deep immunosuppression and a variety …

We aimed to assess patient exposure to isavuconazole (ISZ) from samples received in our
laboratory for therapeutic antifungal monitoring. We used liquid chromatography coupled …

In vitro combination of echinocandins and isavuconazole against the emerging species
Candida auris is mainly synergistic. However, this combination has not been evaluated in …

Background Fungal brain abscesses in immunocompetent patients are exceedingly rare.
Cladophialophora bantiana is the most common cause of cerebral phaeohyphomycosis, a …

Coccidioidal meningitis (CM) is a life-threatening infection with limited treatment options.
Small series have reported success with isavuconazole; however, limited data exist on …