Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and
cardiovascular disease. In the past decade, a large number of endocrine, inflammatory …

Background: As the prevalence of adiposity soars in both developed and developing
nations, appreciation of the close links between obesity and disease increases. The strong …

The rapid increase in the prevalence and severity of obesity in children is likely to lower the
age of onset and increase the incidence of cardiovascular disease worldwide …

Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …

Adipocyte dysfunction is strongly associated with the development of obesity and insulin
resistance. It is accepted that the regulation of adipocytokine expression is one of the most …

In multicellular organisms, insulin/IGF signaling (IIS) plays a central role in matching energy
needs with uptake and storage, participating in functions as diverse as metabolic …

Context: Retinol binding protein (RBP4), secreted primarily from the liver and adipose
tissues, was recently proposed as a link between obesity and insulin resistance. The role of …

Context: High retinol-binding protein 4 (RBP4) is thought to be associated with insulin
resistance in humans. However, evidence from large-scale populations about the …

Insulin resistance occurs under conditions of obesity, metabolic syndrome, and type 2
diabetes. It was found to be accompanied by down-regulation of the insulin-responsive …

Background—Retinol-binding protein 4 (RBP4) may play an important role in the origin of
insulin resistance and metabolic syndrome. Few prospective data are available on the …