Pharmacology of heparin and related drugs
B Mulloy, J Hogwood, E Gray, R Lever, CP Page - Pharmacological reviews, 2016 - ASPET
Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …
decades and is still widely used in clinical practice for a variety of indications. The …
Oligosaccharide analysis by mass spectrometry: a review of recent developments
Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …
Applications of fourier transform ion cyclotron resonance (FT-ICR) and orbitrap based high resolution mass spectrometry in metabolomics and lipidomics
Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major
approaches aimed at understanding the organization and dynamics of metabolic networks …
approaches aimed at understanding the organization and dynamics of metabolic networks …
Targeting heparin and heparan sulfate protein interactions
Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are
made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars …
made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars …
Homogeneous low-molecular-weight heparins with reversible anticoagulant activity
Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically
used to treat thrombotic disorders, but impurities, structural heterogeneity or functional …
used to treat thrombotic disorders, but impurities, structural heterogeneity or functional …
Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins
Y Xu, K Chandarajoti, X Zhang, V Pagadala… - Science translational …, 2017 - science.org
Low–molecular weight heparin (LMWH) is used clinically to treat clotting disorders. As an
animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant …
animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant …
Analysis of glycosaminoglycan-derived, precolumn, 2-aminoacridone–labeled disaccharides with LC-fluorescence and LC-MS detection
N Volpi, F Galeotti, B Yang, RJ Linhardt - Nature protocols, 2014 - nature.com
Glycosaminoglycans (GAGs) possess considerable heterogeneity in average molecular
mass, molecular mass range, disaccharide composition and content and position of sulfo …
mass, molecular mass range, disaccharide composition and content and position of sulfo …
Spectroscopic characterization, cyclic voltammetry, biological investigations, MOE, and gaussian calculations of VO (II), Cu (II), and Cd (II) heteroleptic complexes
A novel hydrazone ligand (o-H2BMP) N-(benzo [d] thiazol-2-yl)-3-oxo-3-(2-(1-(pyridin-2-yl)
ethylidene) hydrazinyl) propanamide alongside its Cu (II), Cd (II), and VO (II) complexes …
ethylidene) hydrazinyl) propanamide alongside its Cu (II), Cd (II), and VO (II) complexes …
Analysis of the glycosaminoglycan chains of proteoglycans
Glycosaminoglycans (GAGs) are heterogeneous, negatively charged, macromolecules that
are found in animal tissues. Based on the form of component sugar, GAGs have been …
are found in animal tissues. Based on the form of component sugar, GAGs have been …
Developments in mass spectrometry for glycosaminoglycan analysis: a review
This review covers recent developments in glycosaminoglycan (GAG) analysis via mass
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …