As important reactive species, isoindolinones represent a cluster of valuable building blocks
for the construction of natural‐product‐like compounds. In particular, chiral isoindolinones …

The construction of tetrasubstituted carbon centers (especially chiral ones) represents one of
the most challenging and demanding topics in the synthesis of natural products and related …

The asymmetric synthesis of alkynyl and monofluoroalkenyl isoindolinones from N‐methoxy
benzamides and α, α‐difluoromethylene alkynes is enabled by C− H activation with a chiral …

An enantioselective aerobic decarboxylative Povarov reaction of N-aryl α-amino acids with
methylenephthalimidines through cooperative photoredox and chiral Brønsted acid catalysis …

The catalytic enantioselective synthesis of isoindolinones was achieved through the
condensation of 2‐acyl‐benzaldehydes and anilines. In the presence of 1 mol% of a chiral …

An enantioselective copper-catalyzed 1, 2-arylboration reaction of enamines has been
developed by employing (R)-xyl-BINAP as a chiral ligand. A number of chiral borate …

Chiral Brønsted acid catalyzed enantioselective syntheses of isoindolinones and phthalides
have been accomplished via tandem Mannich-lactamization and aldol-lactonization …

Chiral quaternary ammonium ion-pair organocatalysis has been widely used in the facile
synthesis of chiral molecules with challenging stereocenters. Especially, numerous …

We herein report the ammonium salt‐catalyzed synthesis of chiral 3, 3‐disubstituted
isoindolinones bearing a heteroatom functionality in the 3‐position. A broad variety of …

Cascade reactions of ortho-carbonyl-substituted benzonitriles with ((chloromethyl) sulfonyl)
benzenes as pronucleophiles led to new isoindolin-1-ones with a tetrasubstituted C-3 …