BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

OBJECTIVE: To summarize the information regarding pathogenetic factors of leiomyoma
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …

Background: Uterine leiomyomas (fibroids) are the most common benign estrogen-
dependent tumors of premenopausal women. TGF-β3 up-regulates the synthesis of many of …

STUDY QUESTION Can biologically active vitamin D3 [1, 25 (OH) 2D3] regulate the
expression and activity of matrix metalloproteinases (MMPs) in human uterine fibroid cells …

BACKGROUND Uterine fibroids are the most common gynecologic tumors in women of
reproductive age yet the etiology and pathogenesis of these lesions remain poorly …

Uterine leiomyoma are common, benign tumors that are enriched in extracellular matrix. The
tumors are characterized by a disoriented and loosely packed collagen fibril structure similar …

OBJECTIVE: Uterine leiomyoma produce an extracellular matrix (ECM) that is abnormal in
its volume, content, and structure. Alterations in ECM can modify mechanical stress on cells …

Vitamin D is essential for the proper functioning of the human body. There is also evidence
of its strong association with fertility problems in women. This review aims to evaluate the …

Transforming growth factor β (TGFβ) superfamily is evolutionarily conserved and plays
fundamental roles in cell growth and differentiation. Mounting evidence supports its …

OBJECTIVE: To examine the effect of transforming growth factor (TGF) β3 on immortalized
myometrial and leiomyoma cell lines cloned from primary cell cultures of surgical …