Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …

Regulatory T (Treg) cells are crucial for peripheral immune tolerance and prevention of
autoimmunity and tissue damage. Treg cells are inherently defined by the expression of the …

Regulatory T (Treg) cells, possess a strategic role in the maintenance of immune
homeostasis, and their function has been closely linked to development of diverse …

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.
However, cholesterol metabolism as a key component of this regulation remains largely …

Mucus produced by goblet cells in the gastrointestinal tract forms a biological barrier that
protects the intestine from invasion by commensals and pathogens. However, the host …