Since its discovery, ADAM17, also known as TNFα converting enzyme or TACE, is now
known to process over 80 different substrates. Many of these substrates are mediators of …

Recent studies have demonstrated a critical role for nerves in enabling tumor progression.
The association of nerves with cancer cells is well established for a variety of malignant …

Head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate of 50%.
One potential reason for treatment failure is the presence of cancer stem cells (CSCs) …

Purpose: Given that nerve growth factor has previously been shown to be involved in breast
cancer progression, we have tested here the hypothesis that the other neurotrophins (NT) …

Cancers of the digestive system, including esophageal, gastric, pancreatic, hepatic, and
colorectal cancers, have a high incidence and mortality worldwide. Efficient therapies have …

Stem cells are permanent residents of tissues and thought to be targets of cancer initiation.
The frequent, and often early, upregulation of the FOXM1 transcription factor in the majority …

The p75 neurotrophin receptor (p75 NTR) is expressed on many cell types and can
influence a variety of cellular functions. This receptor can mediate cell survival or cell death …

Neurotrophin receptors are emerging targets in oncology, but their clinicopathologic
significance in thyroid cancer is unclear. In this study, the neurotrophin tyrosine receptor …

Cancer stem cells (CSCs), are thought to be at the origin of tumor development and
resistance to therapies. Thus, a better understanding of the molecular mechanisms involved …

Summary c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells,
and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation …