Materials control of the epigenetics underlying cell plasticity
The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …
Nutriepigenomics in environmental-associated oxidative stress
K Rubio, EY Hernández-Cruz, DG Rogel-Ayala… - Antioxidants, 2023 - mdpi.com
Complex molecular mechanisms define our responses to environmental stimuli. Beyond the
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
In breast cancer, the increased stiffness of the extracellular matrix is a key driver of
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …
Biphasic regulation of epigenetic state by matrix stiffness during cell reprogramming
We investigate how matrix stiffness regulates chromatin reorganization and cell
reprogramming and find that matrix stiffness acts as a biphasic regulator of epigenetic state …
reprogramming and find that matrix stiffness acts as a biphasic regulator of epigenetic state …
Synergistic effects of mechanical stimulation and crimped topography to stimulate natural collagen development for tendon engineering
Suitable scaffold structures and mechanical loading are essential for functional tendon
engineering. However, the bipolar fibril structure of native tendon collagen is yet to be …
engineering. However, the bipolar fibril structure of native tendon collagen is yet to be …
Reduced endometrial expression of histone deacetylase 3 in women with adenomyosis who complained of heavy menstrual bleeding
C Mao, X Liu, SW Guo - Reproductive BioMedicine Online, 2023 - Elsevier
Research question What role, if any, does histone deacetylase 3 (HDAC3) play in
adenomyosis-associated heavy menstrual bleeding (HMB)? Design Seventy-two women …
adenomyosis-associated heavy menstrual bleeding (HMB)? Design Seventy-two women …
Effects of forces on chromatin
Chromatin is a unique structure of DNA and histone proteins in the cell nucleus and the site
of dynamic regulation of gene expression. Soluble factors are known to affect the chromatin …
of dynamic regulation of gene expression. Soluble factors are known to affect the chromatin …
Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation
J Mishra, S Chakraborty, Niharika, A Roy… - Journal of Cellular …, 2024 - Wiley Online Library
Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …
Polyvinyl alcohol/gelatin hydrogels regulate cell adhesion and chromatin accessibility
Cell adhesion has a critical influence on various processes such as cancer metastasis and
wound healing. Many substrates have been used for studying cell adhesion and its related …
wound healing. Many substrates have been used for studying cell adhesion and its related …