Stable peptide-assembled nanozyme mimicking dual antifungal actions

Y Yuan, L Chen, K Song, M Cheng, L Fang… - Nature …, 2024 - nature.com
Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic
candidates against antimicrobial resistance but suffer from low efficiency and poor stability …

[HTML][HTML] Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the …

J Fantini, F Azzaz, C Di Scala, A Aulas… - Pharmacology & …, 2025 - Elsevier
The traditional model of protein structure determined by the amino acid sequence is today
seriously challenged by the fact that approximately half of the human proteome is made up …

Exploring cross-α amyloids: from functional roles to design innovations

S Dey, R Kumar, R Mishra, S Bera - Trends in Biochemical Sciences, 2024 - cell.com
Amyloids are filamentous protein aggregates that have traditionally been associated with
neurodegenerative diseases, although they are also known to play pivotal functional roles …

Interferon lambda 4 is a gut antimicrobial protein

X Xiao, J Wang, J Ma, X Peng, S Wu, X Chen… - Proceedings of the …, 2024 - pnas.org
To withstand complex microbial challenges, the mammalian gut largely depends on the
secretion of diverse antimicrobial proteins. Type III interferons (IFNλs) are ordinarily …

Advances in Developing Small Molecule Drugs for Alzheimer's Disease

W Zhang, L Zhang, M Lv, Y Fu, X Meng… - Current Alzheimer …, 2024 - benthamdirect.com
Alzheimer's disease (AD) is the most common type of dementia among middle-aged and
elderly individuals. Accelerating the prevention and treatment of AD has become an urgent …

Non-standard proteins in the lenses of AlphaFold3-case study of amyloids

AW Wojciechowska, JW Wojciechowski, M Kotulska - bioRxiv, 2024 - biorxiv.org
The recent release of AlphaFold3 raises a question about its powers and limitations. Here,
we analyze the potential of AlphaFold3 for correct reproduction of amyloid structures, which …

[PDF][PDF] The Kinetics and Thermodynamics of the Amyloid Beta Peptide

M Lindberg - 2024 - lup.lub.lu.se
Amyloids are a category of protein structures where many individual polypeptide chains fold
to form long β-sheet fibrils. These are strongly associated to many of today's incurable and …