The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Cancer cell possesses numerous adaptations to resist the immune system response and
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …

18.1. 1 Extracellular Vesicles The direct contact between two or more cells and the
interaction between the ligand and the receptor have been considered, for a long time, the …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Activation of scramblases is one of the mechanisms that regulates the exposure of
phosphatidylserine to the cell surface, a process that plays an important role in tumour …

Plasma membrane rupture is a promising strategy for drug-resistant cancer treatment, but its
application is limited by the low tumour selectivity of membranolytic molecules. Here we …

Tissue macrophages rapidly recognize and engulf apoptotic cells. These events require the
display of so-called eat-me signals on the apoptotic cell surface, the most fundamental of …

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for
the treatment of hematological malignancies. However, in patients with solid tumors …

Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various
applications. While the current delivery method relies on the drainage of nanoparticles to …

CD47 acts as a" don't eat me" signal that protects cells from phagocytosis by binding and
activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro …